casno. : CAS 1177-87-3
The main difference between dexamethasone acetate and dexamethasone, is in the combination of the dry compounds. Dexamethasone acetate is a salt-forming compound consisting of dexamethasone acetate and acetic acid root, the main components, in the form of a chemical bond. Dexamethasone acetate is more stable and has been optimized in terms of its physicochemical properties. There is usually no difference between dexamethasone acetate and dexamethasone in terms of clinical efficacy and adverse effects, and dexamethasone acetate is often referred to as dexamethasone.
|Chinese name||Dexamethasone Acetate|
Dexamethasone acetate tablets are an adrenocorticotropic hormone drug, which is an oral preparation with anti-inflammatory, anti-allergic, anti-rheumatic as well as immunosuppressive effects. It is mainly used in allergic and autoimmune diseases, mostly in rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, myositis, scleroderma, but also in severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukemia, etc.
It can also be used for certain serious infections, such as sepsis, toxic shock and comprehensive treatment of malignant lymphoma, and is very widely used in clinical practice. In addition, the more common drug allergy or allergic rash of unknown origin can also be treated with dexamethasone acetate tablets. Dexamethasone acetate tablets can also be used for anti-inflammatory and antipyretic relief of symptoms if fever and joint swelling and pain occur.
Adrenocortical hormone drugs have more significant anti-inflammatory, anti allergic and anti shock effects than prednisone, but have less effect on water and sodium retention and promoting potassium excretion, and have stronger inhibitory effect on pituitary adrenal gland.
Anti inflammatory effect: This product can reduce and prevent the reaction of tissues to inflammation, thus reducing the expression of inflammation. Hormones inhibit the aggregation of inflammatory cells, including macrophages and leukocytes, at inflammatory sites, and inhibit phagocytosis, the release of lysosomal enzymes, and the synthesis and release of inflammatory chemical mediators. It can reduce and prevent the reaction of tissues to inflammation, thus reducing the expression of inflammation.
Immunosuppressive effect: it includes preventing or inhibiting cell-mediated immune reaction, delayed allergic reaction, reducing the number of T lymphocytes, monocytes and eosinophils, reducing the binding ability of immunoglobulin and cell surface receptors, and inhibiting the synthesis and release of interleukin, thus reducing the transformation of T lymphocytes to lymphoblasts and reducing the expansion of primary immune response. It can reduce the immune complex passing through the basement membrane, and reduce the concentration of complement components and immunoglobulin.